Voltage-Gated Calcium Channels reviews major advances in the molecular physiology of voltage-gated calcium channels. It highlights structural insights from X-ray crystallography and cryo-EM, discoveries of disease-associated channel mutations through genome sequencing, and functional studies using in vivo models such as knock-in and knock-out mice. The chapters also discuss regulatory complexity from mRNA editing and splicing, and summarize current calcium channel inhibitors and their therapeutic potential. The book is intended for researchers in neuroscience, biophysics, cell biology, and drug discovery.

Pathologies of Calcium Channels explores human diseases caused by dysfunction of calcium channels, key regulators of cellular calcium signaling and essential physiological processes. It examines the molecular mechanisms underlying calcium channelopathies, from their roles in normal development and physiology to their involvement in diverse disorders. Written by leading international experts, the chapters review current knowledge of disease-associated calcium channels and discuss their potential as therapeutic targets.